Why is it said to take gastric medicine before taking pain medicine?
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Certain substances called prostaglandins play one of the main roles in creating the sensation of pain in the nerves. Pain medications in the NSAID group work by inhibiting the production of this prostaglandin. But some prostaglandins are involved in various house keeping functions of our body such as controlling the production of acid from the stomach. This means that if prostaglandin decreases, acid production will increase. This is why any anti-ulcerent (commonly known as gastric medicine) is prescribed along with pain medication. Omeprazole, esomeprazole takes some time to start working so it is recommended to take it half an hour before. Rabeprazole starts working relatively quickly.
NSAIDs are the most common type of medication we give patients for pain. These drugs reduce the production of a type of PG by blocking the arachidonic acid pathway that protects the stomach from HCl by producing mucus in the stomach. As a result, the possibility of stomach ulcer increases a lot. In this case, gastric drugs or PPIs are given to patients so that the problem of gastric ulcer does not increase